Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
Identifieur interne : 001034 ( Main/Exploration ); précédent : 001033; suivant : 001035Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
Auteurs : Anthony N. Carlsen [Canada] ; Quincy J. Almeida [Canada] ; Ian M. Franks [Canada]Source :
- Neuropsychologia [ 0028-3932 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000113
- to stream PascalFrancis, to step Corpus: 000148
- to stream PascalFrancis, to step Curation: 000B19
- to stream PascalFrancis, to step Checkpoint: 000039
- to stream Main, to step Merge: 001046
- to stream Main, to step Curation: 001034
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease</title><author><name sortKey="Carlsen, Anthony N" sort="Carlsen, Anthony N" uniqKey="Carlsen A" first="Anthony N." last="Carlsen">Anthony N. Carlsen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Human Kinetics, University Ottawa, 352-125 University Private</s1><s2>Ottawa, ON K1N 6N5</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON K1N 6N5</wicri:noRegion></affiliation></author><author><name sortKey="Almeida, Quincy J" sort="Almeida, Quincy J" uniqKey="Almeida Q" first="Quincy J." last="Almeida">Quincy J. Almeida</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University</s1><s2>Waterloo, ON</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Waterloo, ON</wicri:noRegion></affiliation></author><author><name sortKey="Franks, Ian M" sort="Franks, Ian M" uniqKey="Franks I" first="Ian M." last="Franks">Ian M. Franks</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Kinesiology, University British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0107113</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0107113 INIST</idno><idno type="RBID">Pascal:13-0107113</idno><idno type="wicri:Area/PascalFrancis/Corpus">000113</idno><idno type="stanalyst">FRANCIS 13-0107113 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000148</idno><idno type="wicri:Area/PascalFrancis/Curation">000B19</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000039</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000039</idno><idno type="wicri:doubleKey">0028-3932:2013:Carlsen A:using:a:startling</idno><idno type="wicri:Area/Main/Merge">001046</idno><idno type="wicri:Area/Main/Curation">001034</idno><idno type="wicri:Area/Main/Exploration">001034</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease</title><author><name sortKey="Carlsen, Anthony N" sort="Carlsen, Anthony N" uniqKey="Carlsen A" first="Anthony N." last="Carlsen">Anthony N. Carlsen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>School of Human Kinetics, University Ottawa, 352-125 University Private</s1><s2>Ottawa, ON K1N 6N5</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Ottawa, ON K1N 6N5</wicri:noRegion></affiliation></author><author><name sortKey="Almeida, Quincy J" sort="Almeida, Quincy J" uniqKey="Almeida Q" first="Quincy J." last="Almeida">Quincy J. Almeida</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University</s1><s2>Waterloo, ON</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Waterloo, ON</wicri:noRegion></affiliation></author><author><name sortKey="Franks, Ian M" sort="Franks, Ian M" uniqKey="Franks I" first="Ian M." last="Franks">Ian M. Franks</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Kinesiology, University British Columbia</s1><s2>Vancouver, BC</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, BC</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuropsychologia</title><title level="j" type="abbreviated">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuropsychologia</title><title level="j" type="abbreviated">Neuropsychologia</title><idno type="ISSN">0028-3932</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic stimulus</term><term>Basal ganglion</term><term>Electromyography</term><term>Human</term><term>Motor system disorder</term><term>Parkinson disease</term><term>Reaction time</term><term>Startle reflex</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Stimulus acoustique</term><term>Trouble moteur</term><term>Maladie de Parkinson</term><term>Noyau gris central</term><term>Réflexe sursaut</term><term>Temps réaction</term><term>Electromyographie</term><term>Homme</term><term>Bradykinésie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Carlsen, Anthony N" sort="Carlsen, Anthony N" uniqKey="Carlsen A" first="Anthony N." last="Carlsen">Anthony N. Carlsen</name></noRegion><name sortKey="Almeida, Quincy J" sort="Almeida, Quincy J" uniqKey="Almeida Q" first="Quincy J." last="Almeida">Quincy J. Almeida</name><name sortKey="Franks, Ian M" sort="Franks, Ian M" uniqKey="Franks I" first="Ian M." last="Franks">Ian M. Franks</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001034 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001034 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:13-0107113
|texte= Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.29. |  |